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The accumulation of these mutations entails a fitness cost to the bacterium and leads to DNA loss (McCutcheon and Moran 2012).
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The MC4R has been shown to comprise mutations entailing a substantially elevated body weight (see above) and two polymorphisms, which both have a small protective effect for the development of obesity (see below; e.g. [ 70, 71].
Because this mutation entails a single amino acid substitution, to unambiguously quantify the mutated form of the protein, the MS3 method must successfully interrogate a single peptide in the pool of hundreds of thousands that comprise the sample.
This s*789 (formerly 789) mutant acts similarly to a* mutation in that it entails a red pigmentation and specifically prevents the expression of the Secteur, although it possesses the σ determinant throughout the thallus.
One well studied example is the "petite" mutation in Saccharomyces cerevisiae, which entails a respiratory chain deficiency due to a mtDNA deletion [ 98].
We found a significant correlation between the two types of robustness, although some punctual mutations can entail an opposite effect on these variables.
The presence of hundreds of F mtDNAs in eggs entails a strong buffering effect on deleterious mutations which are complemented by wild-type alleles.
By contrast, the novel 4519_4521delGAT mutation was located in a coding region of the gene, and entails a structural change; namely, the deletion of an aspartate amino acid residue from the acidic tail of the finished HMGB1 protein.
This scenario entails a possibility that β4GalNAcTA/B is involved in the generation of glycan acceptors for DSiaT, and therefore, the mutations in these genes would affect DSiaT-mediated processes.
A strategy like this entails a risk.
Primary marriage always entails a bride-price.
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