Sentence examples for mutations each with from inspiring English sources

Several methods have been developed for molecular analysis of MPN-related mutations, each with different analytical and diagnostic sensitivities.

After applying the frequency cutoff of 2%, our dataset included 398 distinct single nucleotide mutations, each with 3260 observation counts on average.

Multiple rare mutations, each with a minor marginal genetic effect, but collectively may make large contributions in the population.

Thus three different libraries with varying frequencies of mutations, each with approximately 2.5 × 105 recombinant E. coli clones, were established.

– unable to score, NA – not applicable There have been numerous methods employed to detect TP53 mutations, each with its particular advantages and disadvantages.

Although quantitative results for the normal state would be expected to be normally distributed, positive results would not, as they combine many (known or potential) different mutations, each with its own distribution.

These seminal studies concluded that although alterations in Wnt, K-Ras, and p53 pathways remain pivotal to tumor formation, a large number of mutations – each associated with a small fitness advantage – are likely to be involved in tumor progression.

To disentangle the effects of population growth and purifying selection, we compared simulated loci with neutral mutations to those with deleterious mutations, each in population models with and without a recent epoch of exponential growth.

According to our results, both scenarios are likely to involve populations with large numbers of accumulated driver mutations (or, although not considered in our study, fewer driver mutations but each with larger selective effect), which ostensibly contribute to the speed of relapse.

Mutations in each (with a slightly more profound effect on the double-mutant) putative TCF/Lef binding site significantly reduced TCF4/LiCl-dependent activation of Uchl1p-Luc reporters (Fig. 4B, fourth column of each group).

In contrast, a multimutant with 14 mutations each found to stabilize TIM independently was destabilized by 2 °C.