Sentence examples for mutations driven by from inspiring English sources
We suspect that the conditional model may be better because many mutations could be compensating for other mutations driven by HLA immune pressure.
For their relatively distant location from the receptor-binding site, HA1 166, 166 and 264 are probably mutations driven by existing human immunity for antibody escape.
The Nuclear Receptor superfamily shows amazing diversity in the ligand binding cavity brought about by such mutations, driven by strong divergent selection and adaptive positive selection [ 37].
Enhanced mutation is also observed in the promoters of snoRNA and snRNA genes, again particularly in the case of AID* genomes, whereas no statistically significant differences are observed between any of the promoter subsets for mutations driven by EMS.
Although, the functional shifts caused by amino acid changes in PSGs are often unclear, mutations driven by positive selection appear to contribute significantly to the evolution of the phenotypes generated by the PSGs.
The fraction of amino acid mutations driven by positive selection, α, is estimated using three slightly different approaches based on the MK test [ 7], as implemented in the DoFEv2 software package (kindly provided by A. Eyre-Walker).
These mice express the p53R172H mutation driven by the whey acidic protein promoter [33].
Female mice with cardiac-specific overexpression of mutant HSPB5 containing the R120G mutation, driven by the α-myosin heavy chain promoter, have been described previously [8].
A breeding colony of transgenic mice carrying the hA53T mutation driven by the mouse prion promoter was established according to previously characterized mice [28].
Positive selection analysis and correlation with disease progression revealed L10I, a PI resistance minor mutation and a positively selected mutation driven by host immune response, to be detrimental to host.
The following expression plasmids were used: pbcat, kindly donated by Dr H Clevers, Utrecht, NL, contains human β-catenin cDNA with an activating S33Y mutation driven by the strong CMV promoter.
