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However, elc‐1 RNAi compromised reproduction independently of HIF‐1 (this study), whereas vhl‐1 mutations do so in a HIF‐1‐dependent manner (Mehta et al., 2009).
In general, about 80% of NSCLCs with EGFR mutation respond to EGFR-TKIs, whereas 10% of tumors without EGFR mutations do so [ 13].
According to the data for 1170 patients, more than 70% of NSCLCs with EGFR mutations respond to EGFR-TKIs, whereas 10% of tumours without EGFR mutations do so (Table 1).
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For a moment, imagine all women with the BRCA mutations did so.
Moreover, the SDR-ELISA system is capable of discriminating DNA sequences with single base mutations, and do so in a high-throughput manner by detection and quantification of up to 96 or 384 DNA samples in a single shot.
Most patients will reach ESRD before the age of 30 years, while a subset of them with milder mutations will do so at older ages, even after 50 years.
Fifth, bacterial outer cell walls can be easily lost, requiring only two gene mutations to do so [ 201– 201].
Another avenue of research is why Wnt pathway mutations frequently give rise to intestinal cancers, whereas Notch pathway mutations have not been found to do so.
They do so by adding mutations to the viruses as they replicate.
Those mitochondrial mutations that do induce autophagy may do so by causing energetic stress, by specific signaling such as the ROS that have been proposed to induce autophagy (reviewed in [25]), or by affecting the permeability transition that has also been proposed to play this role [22], [26].
Chromosomal mutations which result in resistance can do so by a variety of mechanisms, which can broadly be divided into target-site and non-target-site mechanisms (Andersson and Hughes 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com