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The p53 frameshift mutations do not appear to occur as a consequence of genomic instability.
Due to redundancies in the genetic code, many of these mutations do not result in a change in amino acid.
What's more, these mutations do not affect the interactions between MrkH and c-di-GMP (Fig. S2H J).
We show that these mutations do not alter the substrate specificity and signal transduction through Raf-1.
Rather is meant that mutations do not occur according to need.
This means that most mutations do not improve fitness: There are many more ways of making things worse than of making them better.
Multiple genetic variants have been linked to risk of Parkinson disease (PD), but known mutations do not explain a large proportion of the total PD cases.
Although molecular genetic alterations have been characterized in human astrocytomas, many of the mice engineered with these mutations do not develop astrocytomas.
The structure of uPARH47C/N259C in complex with ATF resembles the wild-type uPAR·ATF complex, demonstrating that these mutations do not perturb the uPA binding properties of uPAR.
The information cannot be "untold," and chronic diseases and mutations do not go away.
Generally, cancer gene mutations do not occur randomly.
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