Sentence examples for mutations discovered by from inspiring English sources
Haplotypes were inferred by the PHASE program [34], [35] based on the mutations discovered by sequencing.
On the other hand, the B-SIFT score distribution for somatic mutations discovered by large-scale sequencing projects has a noticeable bump near zero, suggesting that there is indeed a larger portion of these mutations that are not functionally relevant.
The precision was 0.866, meaning that the sequencing approach missed about 13% of the mutations discovered by the aCGH approach.
However, a closer look at the mutations discovered by Jones et al. through exome sequencing [ 10] revealed that only KRAS and BRAF were recurrently mutated in LGSC.
Further advances in such studies are expected to uncover the biological significance of disease-associated mutations discovered by genome-wide association studies [ 41] and help in identifying biomarkers and novel drug targets [ 39].
In the future, our method to infer the primary site of tumor cells may be applicable to mutations discovered by sequencing of circulating tumor DNA in blood or urine, which may be applied for early detection or monitoring of cancer, as deep sequencing of low levels of tumor DNA becomes increasingly possible [ 44].
The second mutation discovered by Frost et al. was a substitution of T with C predicted to replace codon 575 leucine with proline [ 2].
MutSigCV [ 35] analyzes lists of mutations discovered in DNA sequencing, to identify genes that are mutated more often than expected by chance given background mutation processes.
If this FALS-SALS percentage ratio were to remain the same when 100% of FALS-causing mutations are discovered, by extrapolation only 16% of SALS patients will harbour ALS-causing mutations.
All of the mutations discovered from the mutation analysis are single nucleotide polymorphisms (SNPs) and were confirmed by Sanger sequencing.
However, most pro-longevity mutations are discovered by systematic gene deletion or RNA interference screens, which mainly reveal abolished or diminished gene functions [ 1].
