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This line of thought directed us to formulate the question of how much the biology of basal-like tumors with BRCA1 mutations differs from the biology of basal-like tumors without BRCA1 mutations.
The primary aims of the study are to determine whether: (1) The prognosis of patients with breast cancer who harbour BRCA1 or BRCA2 gene mutations differs from non carrier patients after adjustment for age and other major prognostic indicators.
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The patterns of these mutations differ from cell to cell and from patient to patient.
In cluster 2 only the frequency of non-synonymous mutations differed from the neutral expectation.
BRCA1 germline mutations differ from those that affect BRCA2 with regard to the relative risk of developing other solid tumors.
The spectrum of C. briggsae mtDNA base substitution mutations differed from the spectrum previously observed in C. elegans.
Only the frequency of non-synonymous mutations differed from the neutral expectation in the cluster 2 strain.
Even in one breast cancer cell line, 1 % of the mutations differ from cell to cell [ 39].
The histopathological features of breast tumours from patients with BRCA1 and BRCA2 mutations differ from each other and from sporadic breast cancers (Lakhani et al, 1998).
The Y226X and Q227X mutations differ from the previously reported truncating mutations since they result in two C-terminally truncated proteins lacking almost only the GPI anchor.
However it should be noted that the nature of somatic JMML-associated PTPN11 mutations differ from the germline mutations identified in Noonan syndrome in that JMML-associated PTPN11 alleles usually encode stronger gain-of-function mutant proteins [ 200, 201].
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