Sentence examples for mutations destabilizing a from inspiring English sources

Excess E10 inclusion in FTDP-17 can be caused by intronic mutations destabilizing a stem-loop protecting the 5′ splice site at the E10/intron 10 junction.

This mutation destabilizes a disordered binding site embedded in a longer disordered (fuzzy) segment in the tooth of the Head.

The 10 + 16 mutation destabilizes a stem loop structure in intron 10 leading to a 2 6-fold increase of exon 10-containing mRNA in patients (15, 16).

Oncogenic IDH1R132H mutation destabilizes an IDH1 "regulatory segment," which otherwise restricts compound access to the allosteric pocket.

Analysts cited the coup as an example of how Colonel Qaddafi's overthrow could yield unexpected political mutations, destabilizing parts of the vast Sahara region.

Based on the structure of the RAG1-RAG2 protein complex, missense mutations leading to SCID or OS can be categorized into four groups: (1) mutations destabilizing the tertiary structure of RAG1-RAG2; (2) mutaffectingfecting polar residues involved in DNA binding; (3) mutations surrounding the active sites; and (4) mutations located at the interface of RAG1 and RAG210.

Activating mutations destabilizing inter-domain polar core significantly enhance clathrin and AP2 binding (Milano et al., 2002), likely by increasing overall flexibility of the molecule and the probability of the C-tail release in free arrestins.

As it is explained later in more detail, the inflicted epistatic effects can match or even exceed those associated with the mutations destabilizing proteins.

The active form of the protein is a tetramer; however, point mutations destabilize the tetrameric form, leading to the accumulation of the monomeric form, which seeds amyloid formation.

Substitution of Asp371 by Glu or Asn, and also Glu445 by Asn resulted in a positive value of ΔΔGsolv, suggesting that mutations destabilized the protein structure.

The protease sensitivity of the suppressor mutations indicates that the closed structure determined by X-ray crystallography is an authentic structure in vivo, and that these mutations destabilize the closed state of AP2.