Sentence examples for mutations decrease in from inspiring English sources

Importantly, these mutations decrease in frequency by 12 18 months following exposure to SD-NVP, and can no longer be detected by standard population sequencing [12], [13], [14], and detection requires more sensitive assays [15], [16], [17].

Independent laboratories have consistently observed that changes in Ca2+-sensitivity, ATPase activity, or force development due to cTn mutations decrease in DCM [ 23, 24].

Interestingly, the number of the patient-derived rod cells with distinct mutations decreased in vitro; cells derived from patients with a specific mutation expressed markers for oxidation or endoplasmic reticulum stress, and exhibited different responses to vitamin E than had been observed in clinical trials.

The results demonstrated that the levels of plasma DNA containing sensitizing EGFR mutations decreased in all patients except one after the first 4 weeks of erlotinib treatment (Table 1).

Conversely, the Pfdhps 437G mutation decreased in both groups from 44.6%too 28.6% (P = 0.07) and from 66.7% to 47.5% (P = 0.02) between 2010 and 2011 in the control and the IPTi/c groups, respectively.

Detrimental mutations will decrease in frequency and go extinct.

These data indicate that for this subset of DJ-1 familial mutations, the decrease in interactions with aSyn is due – at least in part – to decreased expression levels, which is likely representative of what occurs in patients.

We find that telomere lengths of TERT mutation carriers decrease in an age-dependent manner and show progressive shortening with successive generations of mutation inheritance.

It should be noted that the mutation-induced decrease in Ca2+ sensitivity was much smaller than that induced by phosphorylation of cTnI [ 35].

Our other studies on the metabolic impact of AMPD1 C34T mutation revealed decrease in AMPD activity, increased production of adenosine and de-inhibition of AMP regulated protein kinase.

First, Tyrp1 mutation or decrease in expression interferes with melanosome maturation in mouse melanocytes and, most interestingly, attenuates cell proliferation, without evidence of necrosis or apoptosis (Sarangarajan et al, 2000).