Exact(27)
We also determined that α-synuclein PD mutants (PARK1/hA30P and PARK4/hα-syn) primarily affected presynaptic cytomatrix proximal to the active zone, congruent with previous findings that these PD mutations decrease neurotransmission.
Importantly, these mutations decrease in frequency by 12 18 months following exposure to SD-NVP, and can no longer be detected by standard population sequencing [12], [13], [14], and detection requires more sensitive assays [15], [16], [17].
All three mutations decrease NP's thermal stability.
Many pairs of mutations decrease raltegravir susceptibility >100-fold.
The disease-causing mutations decrease the mechanical stability of the glomerular basement membrane (GBM).
Most ARV-resistance mutations decrease susceptibility to one or more ARVs of the same class.
Similar(32)
Mutations decreased the hydrolysis activity of the enzyme and caused various modulations in its transglycosylation properties.
All mutations decreased the viral replicative capacity including mutations in residues G359 and K390.
Thus, the M184V resistance mutations decreased quickly after treatment interruption in all five patients.
The number of mutations decreased to a median number of 2 RT mutations and 0 PR mutation during the STI.
Generally, hypothetical mutations active in males deviate from some previous approaches that focused on mutations decreasing female susceptibility to modified sperm [21], [24].
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