Sentence examples for mutations critical for from inspiring English sources

Are all somatic mutations critical for the development of the tumour in which they are found?

RavA mutations are highlighted as in (A ) and LdcI mutations critical for the RavA binding (E634K and Y697S) are shown in green.

Identifying cancer-associated mutations (driver mutations) is critical for understanding the cellular function of cancer genome that leads to activation of oncogenes or inactivation of tumor suppressor genes.

Since the absence (or presence) of canonical mutations in isolates that harbor novel mutations were critical for this study, we have confirmed the WGS discovery (or lack thereof) of these mutations using the previously published Sanger sequencing and Pyrosequencing results from the same isolates.

Although we were successful in finding mutations that reduced Rs1 constitutive signaling these same mutations adversely affected the agonist mediated signaling (Rs1.2), suggesting that the D66N and W272A mutations are critical for all aspects of Gs signaling.

Thus, it is believed that activating K-ras mutations are critical for initiation of pancreatic ductal carcinogenesis.

Genetics and genetic mutations are critical for evolution, but they are not the only molecular factors to consider.

Ultimately, an improved understanding of the clinical impact of PIK3CA mutations is critical for the development of optimally personalized therapeutics against breast cancer and other solid tumors.

The TMI and TMIV mutations in the α1b-adrenoceptor result not only in defective receptor maturation and delivery to the plasma membrane, but also in alteration of quaternary structure, with the TMIV mutations being critical for this effect [ 18].

The current paper holds that selection on interactions and nonrandom mutation are critical for adaptive evolution.

Nucleotide sequence of the ham5 locus from T. reesei QM6a and T. reesei RL1/A8-02 RL1/A8-02 the mutatincluding critheal for femutationtility.