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That is, we scan the database beyond a particular node from the classification tree only when score 2 is reached for the mutations covered that far.
In contrast, when large follicle-cell clones of the sav, hpo, or wts mutations covered the posterior end of the oocyte, we observed multilayering of the follicular epithelium with smaller nuclear size (Fig. 1B,C, 3G), as well as strong oocyte-nucleus-positioning defects (Fig. 1B,G,J, 2H, 3B,J), similar to recent studies of Hpo signaling in oogenesis [33], [34].
The range of mutations covered is detailed in Supplemental table S1 in Additional file 1.
By clicking on the first column, the user can obtain a list of all mutations covered by each rule.
In our case, the similarity between 2 rules was defined as the number of common deleterious mutations covered by these 2 rules (Jaccard similarity coefficient 47).
As described above, we isolated 115 independent mutant alleles whose causative mutations covered 20 out of 22 GPI-anchor pathway essential genes.
Similar(47)
The mutations cover the entire length of the TP and are arranged at regular intervals.
Among the seven candidate mutations that were confirmed, six were covered by six or more Illumina reads; one candidate mutation covered by five reads was confirmed.
Sphynx (a natural mutation covered with a fine down that resembles the texture of suede).
The first mutation covers nts 3 7, replacing AGAAG with TTTTT (designated as C1).
For example, let us assume there are two point mutations with the same support 3, where the first mutation covers only drug-resistant strains within one subtree of the phylogenetic tree, whereas the second mutation covers the same number of strains but spread throughout the whole tree.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com