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Characterization of suppressor mutations could provide useful information needed to develop therapeutic strategies to repair ΔF508-CFTR.
We also analyzed whether patterns of correlated mutations could provide insight into the intermolecular structural organization of the K-domain helices.
Hypothetically, the alanine mutations could provide additional space to accommodate the methyl groups of H3K4me3 into the acidic fold of G9A.
The identification of patient-specific mutations could provide crucial information regarding molecular pathways underlying cALL tumorigenesis and thus point to new therapeutic avenues.
Discovering of the exact pathogenic mechanisms of IMAGe CDKN1C mutations could provide a basis for developing new therapeutic strategies and targets, both for IMAGe and for other diseases associated with CDKN1C dysregulation.
Because PDIMs and other mycobacterial lipids play an important role in virulence [ 59, 60], this argues that global physiological consequences of drug-resistance mutations could provide a contextual framework, within which the compensatory mechanisms mediated by mutations in ancillary genes can be explored [ 7, 51, 54].
Similar(54)
Part of this nonsense mutation could provide a functional NS5A protein.
93 These data suggest that the use of specific treatments for each mutation could provide additional benefits in the management of metastatic MTC.
This approach might reflect the physiology of the human patients with heterozygous mutations and could provide insights into the development of the CNS and the mechanisms underlying the epilepsy phenotype in PK mutants.
In turn, this elevated mutation rate could provide an underlying genetic mechanism to explain why robustness promotes evolvability.
Even so, with their treatment of a wider class of mutations, the result could provide a mathematical foundation for understanding the ebb and flow of many different strategies in the games nature plays.
More suggestions(15)
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