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Exact(14)
Called the DNA damage response, this network senses the problem and sends a signal to the rest of the cell so it can properly repair itself; otherwise, severe mutations could occur.
These mutations could occur anywhere in the cloning cassette, including the stem, the loop, and sequences outside the stem-loop.
At the beginning of a neutral genome shrinkage process, there would be few constraints on what mutations could occur.
The number of mutants is higher when the net growth is lower because more cell turnover has occurred at a given detection size, thereby creating more replication events during which mutations could occur.
The large population size of prokaryotes may imply that events considered as relatively rare (e.g. genetic mutations) could occur relatively frequently.
In these simulated lineages, four types of mutations could occur: segmental duplications, large deletions, small insertions and small deletions.
Similar(46)
Therefore, compensatory changes in the genetic background of the key position 76 PfCRT CQR mutation could occur at several levels.
Additionally, a mutation could occur in a branch leading to a phylogenetic node yet only became "nodal" in a particular subnode.
Alternatively, one mutation could occur as subclonal evolution in a cell that already contains the other mutation, in which case we would see reads that report the earlier variant only as well as reads that report both variants together.
To generate a sterile clone with fitness 2% greater than the population mean, a 1.5%-effect sterile mutation could occur in a population with less variation in fitness than is needed for a 0.6%-effect sterile mutation.
The most adaptive mutation could occur in either R → A ← L or C ← L, which led to stochastic outcomes similar to those observed in well-mixed liquid cocultures (Waite and Shou, 2012 ).
More suggestions(15)
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