Sentence examples for mutations could impair from inspiring English sources

It is tempting to speculate that PINK1 mutations could impair the function of the UPS.

Thus, whilst SDHD mutations could impair oxygen sensing, low altitude may serve to reduce the penetrance of these mutations.

These mutations could impair recruitment of TFs to enhancers, potentially disrupting tissue- and lineage-specific gene expression and, consequently, development.

In addition, it has been proposed that PSEN mutations could impair other γ-secretase-dependent and -independent functions of PSEN.

However, as residues mutated in CMT2B are not near the catalytic glutamine (Q67) or the hydrolyzed γ-phosphate of GTP, it was unclear how disease mutations could impair GTPase activity.

Thus, the natural mdx mutation could impair splicing efficiency by reducing the binding of a 40 kDa SR protein to exon 23 ESE.

This mutation could impair the DNA binding of and transcription activation by PhoP and may be partly related to attenuation of virulence in H37Ra.

Several of the mutations observed in MeCP2 associated with RTT are located near putative phosphorylation sites – mutation of the Arg110 residue could alter the phosphorylation of Ser113 by PKCα/β, mutation of Arg294 might affect phosphorylation of Ser292 by PKCε or PKCδ, and mutations of Arg168 could impair Ser164 phosphorylation by CDKL5 (Fig. 4).

Since many proteins in mitochondria are compartmentalized and tightly organized in functional multi-protein complexes such as the ETC complexes, we investigated if this is also true for PINK1, and if mutations in PINK1 could impair this association.

The mechanism through which mutations in FBXW7 could impair cetuximab or panitumumab efficacy requires further studies.

It is possible that, since some of its proven targets are downstream effectors of EGFR, mutations of FBXW7 could impair their degradation and thus contribute to the resistant phenotype.