Sentence examples for mutations contributed by from inspiring English sources

In addition to deciphering mutational signatures, our approach extracts the number of mutations contributed by each signature to each cancer genome.

Dot plots of the fraction of total mutations contributed by each base (squares) and to which base it was mutated (mutational fate, circles) induced by the restoration of T/G (panel A ) or U/G (panel B ) to C/G on the top strand of FM1 (pooled according to the type of the lesions).

Dot plots of the fraction of the pooled total mutations contributed by each base (squares) and to which base it was mutated (mutational fate, circles) induced by the restoration of lesions to C/G that had been introduced on the bottom strand of FM1 T/G (top panel) or U/G (bottom panel).

Further, our approach was able to accurately identify the number of mutations contributed by each of the ten processes in each of the genomes.

We determined the fraction of total mutations contributed by each base of the reporter and mismatch regions, and the identity of the base to which it was mutated (i.e., its mutational fate), and report these results in terms of the top strand sequence.

The samples were considered in aggregate apart from PD4120a that was excluded because of the nature of the excessive mutation burden contributed by this sample.

Further studies are urgently needed to clarify whether ATP13A2 mutations contribute to PD by increasing susceptibility to cation toxicity.

Studies have shown that KISS1R loss-of-function mutations contribute to nIHH by affecting GnRH secretion, but not olfactory bulb development or GnRH neuronal migration [ 15, 16].

Many mutations contribute to tumorigenesis by causing transcriptional deregulation through epigenetic modifications resulting in aberrant proliferation, impaired differentiation, and impaired apoptosis.

Our results show that the gain of function conferred by PIK3CA mutations contributes to resistance to HER2 inhibitors by partially uncoupling PI3K signaling from HER2 inhibition.

It contains, in total, 3,315 mutations, 3,250 (∼98%) contributed by the three mutational processes and the remaining 65 (∼2%) by white noise corresponding to minor processes or experimental errors in generating the mutation catalog of the genome.