Sentence examples for mutations contribute more from inspiring English sources

These findings show that deaminations during replication and other mutations contribute more than selection on amino acid sequences to strand compositions of G and C, and that the replication process has a stronger affect on A and T content than does transcription.

So there is no clear basis for predicting which mutations contribute more to overall activity versus specificity.

As slightly deleterious mutations contribute more to polymorphisms than to divergence, the SNPs were then classified by the frequency of their rarer allele into low frequency SNPs (< 5%), moderate frequency SNPs (5-15%), and common SNPs 15-500%) following Fay et al.[ 88].

In our study, the sign of GC skew values on individual protein-coding genes was almost identical among analysis for four different partitions of gene sequences, indicating that deaminations occurring during replication, in addition to other mutations, contributed more than selection on amino acid sequences to the strand composition of G and C.

In the same manner, rare mutations implicated in Mendelian forms of stroke, as well as maternally inherited mitrochondrial mutations, could contribute more than common SNPs to the occurrence of cerebrovascular events.

These mutations may therefore contribute more to cancer formation and development than other mutations.

The initial aim of this study was to determine whether mutations in CHMP2B contribute more broadly to ALS pathogenesis.

In order to investigate whether mutations in TBC1D4 contribute more widely to SIR, we sequenced the coding regions of TBC1D4 (21 exons, 3894 nucleotides) in 156 patients from the cohort.

Among the 18 PSSM conservation features in the feature set B (Figure 3B-2), the mutations of isoleucine and leucine contribute more than other features in the breakdown of hydroxylated sites and non-hydroxylated sites.

Therefore, mutations with higher scores (stronger impact on the protein function) occurring in samples with low mutation rates (samples with large s ij ) contribute more in decreasing Z i and thus, P-values.

Assuming that synonymous mutations are neutral, a higher DN/DS than PN/PS ratio is expected in case of ancient adaptive selection, because positively selected mutations rising to fixation in a population would contribute more to divergence than to polymorphism.