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Nevertheless, almost all of the studies to date have focused on identifying homozygous mutations whereas identifying heterozygous mutations continues to be a challenge.
Since the number of identified recessive mutations continues to increase, new tools are needed to consider such information when making mating decisions.
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New mutations continue to be discovered.
This indicates that mutations continue to occur under selection conditions.
This disorder affects 1 in 3500 boys and de novo mutations continue to arise in all populations worldwide (2).
It is noteworthy that new mutations and new classes of mutations continue to be identified in the ABCA4 gene 16 years after its first association with retinal disease.
Cultivation of such a hypermutable strain will be problematic because mutations continue to emerge across the genome and the desired traits might disappear during long-term passages.
Following organogenesis, mutations continue to accumulate in descendant cells derived from the mixed founder population, with the result that cells within an organ are more dissimilar to each other than they are to the zygote.
While successful clones expand in the population, subsequent mutations continue to produce sequence and fitness variation; that is, new clones originate nested within previous clones (Park and Krug 2007; Desai and Fisher 2007).
It is important to note, however, that very few of the animals with pie-1 mutations continued to exhibit the roller phenotype in subsequent generations, suggesting that the rol-6 transgene expression was transient and present only in the F1 generation.
And, of course, mutation continues to produce more genetic variation every generation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com