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Biochemical, cellular and functional analyses of a number of SI mutations constituted the basis for a classification of these mutants into seven phenotypes depending on the intracellular localization and function of SI [9] (Table 1).
However, the "true" mutations constituted just 6% of the total putative polymorphisms.
Furthermore, if I314V was ignored in both the avian and swine N2 subtype, then it appears that the rest of the mutations constituted 0.9% and 2.0% of the avian and swine N2 subtype populations, respectively.
In most heterogeneous tumors, cells with all mutations constituted the major population (Table 1).
The set of identified point mutations constituted the input genotype data for GWAMAR.
The examples of 6,480 deleterious mutations and 1,637 neutral mutations constituted the initial knowledge base.
Similar(52)
The ability of every multicellular organism to fight off dysfunctional, mutated cells (tumors), and/or external factors that can lead to the mutations constitutes an important mechanism controlled by natural selection.
Surprisingly, we also find that function-altering ("damaging") mutations constitute a greater fraction of the non-synonymous variants in this group, which suggests a role for subfunctionalization in coding variation affecting duplicated genes.
Genotypic and phenotypic analysis of HIV-1 resistance mutations constitute one important point for providing guidelines in the choice of antiretroviral regimens and to design lines of rescue treatment for patients holding HIV-1 drug-resistant variants.
The question remains which of the identified mutations constitute good targets for therapeutic intervention in NSCLC?
Mutations constitute the main source of genetic diversity in asexual populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com