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Mutations constitute the main source of genetic diversity in asexual populations.
These mutations constitute the genotype data.
Of these, 6,480 deleterious mutations constitute the positive examples.
The remaining 1,637 neutral mutations constitute the negative examples.
Further, it is unclear based upon current data as to whether the aforementioned ETNK1 mutations constitute the driver mutation for the underlying MPN or MDS/MPN.
In 1998, Guilford and collaborators identified, for the first time, that E-cadherin gene (CDH1) germline mutations constitute the genetic cause of HDGC [ 8].
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Biochemical, cellular and functional analyses of a number of SI mutations constituted the basis for a classification of these mutants into seven phenotypes depending on the intracellular localization and function of SI [9] (Table 1).
Finally, the fact that we have observed in the networks a fairly strong founder effect with a small cluster of haplotypes (separated by single step mutations) constituting the vast majority outside Africa provided further evidence for absence of recombination.
The examples of 6,480 deleterious mutations and 1,637 neutral mutations constituted the initial knowledge base.
The set of identified point mutations constituted the input genotype data for GWAMAR.
In most heterogeneous tumors, cells with all mutations constituted the major population (Table 1).
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