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In mucA, small deletions prevailed (64.7%) with the rest of the mutations consisting of different kinds of transitions (25%) and transversions (8.3%) (Figure 1A).

However, stepwise mutations, consisting of the addition or subtraction of one single repeat unit, are the most common mutations in microsatellite loci in plants, birds and humans [61].

For instance, in previous studies involving GPCRs, Oliveira and coworkers identified networks of correlated mutations consisting of positions involved in ligand binding, G protein coupling, and activation [18], while IJzerman and coworkers carried out an independent two-entropy analysis to determine the potential function of TM positions [19].

In this case, frameshift mutations consisting of mostly CG deletions occurred in 2.5% of the progeny DNAs (Table 1, row 3) (63).

MC2R gene analysis revealed an unusual combination of two homozygous missense mutations, consisting of the novel mutation Y129C and the previously described F278C activating mutation.

We found only synonymous mutations consisting of a C-to-T transition with G157G in exon 2, a T-to-C transition of L471L in the DGR4 domain, and a C-to-T transition with Y537Y in the DGR5 domain in CRC cell lines.

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Similar(52)

A third group of mutations consisted of residues that increased kon without significantly affecting the encounter complexes.

Mutations consist of increasing or decreasing by one the number of bits of random positions of the mutated candidate solution.

One piece, called "Surgical Mutations," consisted of a single leaf displayed in a wooden frame.

There are also a large number of diseases, including myotonic dystrophy type 1 and Fragile X syndrome, where the disease-causing mutations consist of repeats (in non-coding regions of the genome) that are well above the size of repeats found here to generate unusual DNA structures.

Further evaluation of detected nucleotide mutations consisted of Sorting Intolerant From Tolerant (SIFT; blocks.fhcrc.org/sift/SIFT.html) and screening against known databases: NCBI, Cosmic, UniProtKB/Swiss-Prot and JSNP (www.ncbi.nlm.nih.gov/SNP, www.sanger.ac.uk/genetics/CGP/cosmic/, ca.expasy.org/sprot/, snp.ims.u-tokyo.ac.jp/).

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