Sentence examples for mutations considering that from inspiring English sources

The five KRAS amplicons were similarly represented, with 9 to 12 × 103 reads per sample, an excess with respect to the depth of coverage required for accurate assessment of somatic mutations, considering that a 1% variation of a single-base change and multibase deletion will need 5,000-fold 5,000-foldo obtain a good statisticoveragece of 50 variatoobtainds [ 35].

But if those genes are mobile, why have mitochondria retained any genes at all, especially considering that mutations in some of those genes can cause rare but crippling diseases that gradually destroy patients' brains, livers, hearts, and other key organs.

Using simulation of DNA profiles, our goal is to suggest which is the most appropriate way to address likelihood ratio computation in DVI cases, especially to be able to efficiently deal with complicating issues such as mutations or null alleles, considering that data about these latter are limited and fragmentary.

This is as expected considering that mutations occur at low levels in populations.

Regardless, developmental abnormalities of Kölliker's organ may lead to congenital hearing loss, considering that mutations in ion channels (hemichannels, gap junctions, and calcium channels) involved in Kölliker's organ activity share strong links with such types of deafness.

The absence of any effect on fibrillation could not be anticipated considering that mutations quite close to the N-terminus of the nonacetylated protein, such as V16P, have been reported to inhibit aS fibrillation substantially.

For those populations where the spectrum of ABCA4 mutations is known and considering that allelic frequencies differ from one country to another, the use of a cost-effective strategy similar to the one described in this study, based on carrier frequency screenings, might be recommended to assess the estimated (genotypic) prevalence of arSTGD.

Considering that mutations of chromatin remodeling genes have been highlighted in several cancer studies [15 19], we then conducted Sanger sequencing for all the coding regions of these seven genes in different validation sets (samples for validation were selected randomly, however, due to limited volume of DNA samples of each patient, we cannot test all genes in a single validation set).

Importantly, considering that missense mutations do not necessarily change protein function as severely as nonsense or frameshift mutations, we primarily focused on base changes resulting in premature stop codons and indels within coding exons.

Finally, the full interference model [ 20, 21] tries to eliminate the limitations above by considering that beneficial mutations of different selective values can arise in any genetic background.

Considering that dominant mutations in three other tRNA synthetase genes cause neuropathies similar in pathology to CMT2D, these mouse lines will continue to be valuable models of the heterogenous nature of these disorders.