Sentence examples for mutations confirmed that from inspiring English sources

However, applying less stringent cutoff levels to the data obtained from the two ctDNA-negative patients who had GNA11 mutations confirmed that no mutant reads were evident in their tumor cells (0% and 0.07%).

The formation of the same organs in etr1-9 ers1-3 etr1-9 ers1-3 etr1-9 ers1-3re generandd with indetr1-7 ers1-2 etr1-7 ers1-2 etr1-7 ers1-2at loss of the receptors is the basis for formation of the filamentous organs.

We found a total of 80 putative causal mutations in the twelve evolved clones out of 1521 mutations, confirming that most mutations are non-causal (Table 5).

Importantly, in all samples, analysis of germ line DNA by ARMS was negative for BRAF mutations, confirming that any BRAF mutations detected were tumour derived.

The large number of mutations identified in the TILLING screens, i.e. 26 independent mutations, confirms that the genetic resource developed is of high quality.

Overall, 106 out of 121 (88%) patients with a known genetic etiology had homozygous mutations, confirming that neonatal diabetes in the offspring of consanguineous families is usually recessive.

Finally, experimental data for many of the predicted low-risk mutations confirm that they appear to regulate HIFα similarly to WT VHL.

However, the lysosomal accumulation of KIF5B was abolished by the WD motif mutations, confirming that the WD motifs link SKIP to kinesin-1.

Sequencing of the entire region between RPN12a and NPTII did not reveal any additional mutations, confirming that the RPN12a STOP codon-associated G to A mutation was indeed sor1.

Relative specificity (RS) is described in legend of Figure 4. DOI: http://dx.doi.org/10.7554/eLife.02304.028 Combinations of these mutations confirm that the insertion is primarily responsible for the evolution of pyruvate activity.

Figure 2E shows drastic reductions in the Aβ38/Aβ42 and Aβ40/Aβ43 ratios for all FAD– PSEN1 mutations, confirming that the fourth enzymatic turnover of the γ-secretase is actually impaired in cells (native γ-secretase conditions).