Suggestions(1)
Exact(4)
Genetic evidence shows that the mutations conferred an enormous selective advantage on their owners, enabling them to leave almost 10 times as many descendants as people without them.
However, one study in a cohort of 96 MDS patients reported that TET2 mutations conferred an OS, EFS, and AML-free survival advantage (Kosmider et al., 2009).
Especially, BRCA1 mutations conferred an increased risk for ovarian cancer: on average, there were nearly three times as many ovarian cancers in BRCA1 families than in BRCA2 families (0.89 vs 0.32; P=0.091).
It is important to note that the lrx5 single mutant was comparable to the wild type at all stages of development and only in combination with the lrx3 lrx4 mutations conferred an exaggerated growth defect indicative of a synergistic interaction between the LRX genes.
Similar(56)
Y143R/C mutations conferred a high resistance to RAL in vitro and in vivo.
As expected, the combination of these mutations conferred a synthetic phenotype.
This may indicate that the combined mutations conferred a compromised phenotype with low viability.
Unlike the lobe mutations, the large majority of these mutations conferred a decreased readthrough phenotype.
Double CEBPA mutations conferred a decisively favourable overall (P=0.006) and disease-free survival (P=0.013).
The acquisition of 23S rRNA G2576T mutations conferred a biological cost to the S. pneumoniae 1974M1 mutant.
The acquisition of these mutations conferred a fitness cost however, which was further enhanced by the acquisition of a mutation in a RNA methyltransferase implicated in resistance.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com