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Y143R/C mutations conferred a high resistance to RAL in vitro and in vivo.
As expected, the combination of these mutations conferred a synthetic phenotype.
This may indicate that the combined mutations conferred a compromised phenotype with low viability.
Unlike the lobe mutations, the large majority of these mutations conferred a decreased readthrough phenotype.
Double CEBPA mutations conferred a decisively favourable overall (P=0.006) and disease-free survival (P=0.013).
The acquisition of 23S rRNA G2576T mutations conferred a biological cost to the S. pneumoniae 1974M1 mutant.
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Genetic evidence shows that the mutations conferred an enormous selective advantage on their owners, enabling them to leave almost 10 times as many descendants as people without them.
However, one study in a cohort of 96 MDS patients reported that TET2 mutations conferred an OS, EFS, and AML-free survival advantage (Kosmider et al., 2009).
Studies in bacteria and yeast imply mutator mutations confer a selective growth advantage on cells harboring these acquired mutations [ 24, 25].
If mutations confer a proliferative advantage, mutated cells can bypass the in vitro lifespan limit and rapidly replace the existing population [ 14, 15].
The mutations confer a selective advantage to myeloid progenitors at the expense of lymphoid progenitors.
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