Sentence examples for mutations comprise the from inspiring English sources

BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC.

We demonstrate that TERT promoter mutations comprise the most recurrent mutation in adult SHH tumors identified to date and potentially define distinct prognostic subgroups in SHH and Group 4 medulloblastoma patients.

Recently, other molecular events associated with SDH deficiency have been reported, including genome-wide DNA hypermethylation and a specific microRNA profile 11, 12. Tumors with SDHA mutations comprise the most common subtype of SDH-deficient GIST, and demonstrate loss of SDHA protein expression in addition to the loss of SDHB protein expression 13, 14.

The types of driver mutations were similarly distributed between the two categories, whereas selected mutations comprising the high mutation risk (HMR) category (any mutations in ASXL1, SRSF2, IDH1/2, EZH2) were more represented in overt PMF.

Despite the increased frequency of mutation, the R882 mutations comprised the majority of DNMT3a mutations and were associated with a significantly worse prognosis.

Deleterious mutations comprise those leading to a premature stop codon, including nonsense mutations, splice-site mutations, and insertions and deletions affecting reading frame.

Because these two events cannot be distinguished and these mutations comprise <2% of the total data pool, they are considered individual events for all further analyses.

Furthermore, experimental data suggest that indel mutations comprise 3 6% of the total cases of mutations (Abram et al. 2010), which is approximately the values inferred for seven out of the nine HIV-1 genes we analyzed.

In contrast, "passenger" mutations, which comprise the majority of mutations identified, represent genetic events that have no direct or indirect effect on the selective growth advantage of the cell in which it occurred (Stratton et al., 2009; Vogelstein et al., 2013).

Although many caveats exist in the study of activating mutations, B-SIFT provides a starting point by finding mutations that would otherwise have been missed or indistinguishable from the deleterious mutations that comprise the majority of currently identified functional mutations.

Hyperactive or gain-of-function mutations comprise an area of functional analysis that is often overlooked in large-scale mutation analyses.