Sentence examples for mutations compatible with from inspiring English sources

In general, the central method here was to construct the phylogenetic tree that minimized the number of mutations compatible with the sequence data.

This finding indicates that most nucleotide variations in N gene coding sequence were synonymous mutations compatible with ongoing natural selection.

Because disease-related mutations compatible with survival are more likely to be maintained a population, cells prefer to endure deleterious mutations in regulatory pathways (Goh et al. 2007).

A further critical issue concerns the minimum percentage of detectable mutations compatible with the size of the bottleneck that can be observed in blood and the exact timing of these mutations.

Note that a natural frequency close to one or zero could indicate absolute selection for or against a specific amino acid, but could also simply result from the fact that natural evolution has not completely sampled all possible mutations compatible with HA structure and function.

The findings of estrogen and progesterone receptor negativity, lack of ERBB2 overexpression, and overall higher grade in tumors from patients with BRCA1 mutations, compatible with a basal-like molecular phenotype, was confirmed by Lakhani and colleagues [ 44] in a larger series of 217 patients with BRCA1 or BRCA2 mutations, comparing them to 103 patients with sporadic breast cancer.

Targeted, massively parallel DNA sequencing and molecular inversion probe microarray analysis revealed a germline TP53 mutation compatible with Li-Fraumeni-like syndromutationsic mutatiofs of PIK3CA in the endometrial cancer, and a somatic mutation of GNA11 and JAK3 in the PMM.

The wide range in clinical phenotypes associated with telomerase mutations is compatible with the variable genetic penetrance of these mutations and of their effects on telomere shortening.

Sequencing of populations at different evolutionary times shows that the number and type of mutations are compatible with other laboratory evolution experiments, which are characterized by competition between variant clones (Barrick et al. 2009; Bachmann et al. 2012).

We have not attempted a formal population genetics analysis to see if the frequency distribution of mutations is compatible with the neutral theory (such an analysis would be complicated by the need to correct for phylogenetic relationships and the fact that error-prone PCR is biased towards creating certain types of mutations).

On the other hand, the p.R407C mutation is compatible with secretion, but rather may exert its pathogenic effect by disrupting interactions with ADAM proteins.