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Further support for the idea that aldh1a2i26, aldh1a2um22 and aldh1a2u11 represent null mutations comes from rescue experiments, which indicate that the mutant proteins are not functional.

Direct evidence for insensitivity of our method for de novo mutations comes from the high reproducibility of fitness estimates between replicates and the fact that we never observed any new mutations in our sequencing [33].

One suggestion that the tumor microenvironment may be important in understanding the biology of these mutations comes from Mithani et al who showed that these mutations are late events during tumor formation [18].

Indirect evidence for the benefit of these mutations comes from the assessment of the frequency trajectory of rifampicin resistance over the course of the full 2000-generation experiment.

To date, most of our knowledge on the dominance effect of mutations comes from the study of deleterious mutations (Charlesworth B and Charlesworth D 1998; Garcia-Dorado et al. 1999; Lynch et al. 1999).

The Harms paper argued that evolution of the protein does not proceed deterministically, because function-changing mutations require prior rare mutations that do not change the function; the rarity of these permissive mutations comes from the fact they must fulfill numerous requirements.

Similar(54)

The average number of mutations coming from the mother's side was 15, no matter her age, the study found.

The earliest information about how radiation causes gene mutations came from fruit flies, as did an understanding of our daily sleep/waking rhythms.

The resistant strain of Anopheles gambiae s.s used in this study, termed MRS without kdr and Ace1 mutations, came from a field resistant population that originated from the M'be strain in Côte d'Ivoire (West Africa) harbouring the L1014F kdr mutation as well as metabolic resistance.

Mutations come from errors made during the replication of DNA or from exposure to mutagens.

All six mutations coming from German ancestry are highlighted in Van der Waals presentations in red circles in Figure 1B.

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