Sentence examples for mutations causing significant from inspiring English sources

Although it has been shown that mutations causing significant loss of pyrazinamidase activity significantly contribute to pyrazinamide resistance, the mechanism of resistance is not completely understood.

These evaluations have often been made on high-resolution screens among a small set of genes related to a specific cell function [43], or among a set of known deleterious mutations causing significant growth defects [44].

We did find several mutations causing significant enhancement or reduction in ARD thermal stability and/or ATP binding.

Steady-state kinetic measurements and the analysis of the pH dependence of Vmax and Vmax/Km of l-Asn hydrolysis showed that the mutation causes significant alterations in binding and catalytic properties.

As expected, hog1 mutation caused significant reduction in expression of all these genes.

However, the K1487R mutation caused significant increase of UV-induced Rad53 phosphorylation in rad16 (Fig. 7E and F) and rad16 rad26 cells (Fig. 7H and I).

The mutation caused significant distortion of trichomes and altered pavement cell morphology compared to wild type.

Plots comparing Cα chemical shift indexes of wt and mutant proteins also demonstrate that neither the Y75A mutation nor the H83A mutation caused significant changes in the structure of the apoproteins.

We examined the effect of the E682K mutation on the proteolytic processing of APP and found that this mutation caused significant increases in total Aβ and in Aβ1 42/40 levels.

Interestingly, we found the pericyte density elevated in mice carrying an activating mutation (D849N) in PDGFR-β, independent of ectopic PDGF-BB expression, supporting earlier observations that this mutation causes significant receptor signaling in the absence of ligand, or greatly increases sensitivity towards very low amounts of ligand [ 15].

To date, two homozygous VRK1 mutations have been identified in consanguineous families: a nonsense mutation (p.R358X) causing significant reduction of messenger RNA levels due to nonsense-mediated messenger RNA decay, and a missense mutation (p.R133C).