Sentence examples for mutations causing malignant from inspiring English sources

HRM assays were developed to allow screening of the ryanodine receptor gene (RYR1) for potential mutations causing malignant hyperthermia (MH) and/or central core disease (CCD) using the LightCycler 480 System.

One of the earlier studies on mutations causing malignant neoplasms in Drosophila examined 12 recessive lethal mutations affecting the optic neuroblasts and ganglion mother cells in the larval brain, the imaginal discs, and the hematopoietic organs [ 13].

If a cell fails to repair this DNA damage, it could accumulate carcinogenic mutations, causing a malignant transformation.

Some RYR1 mutations also cause malignant hyperthermia susceptibility (MHS) trait and King Denborough syndrome.

An immunosuppressive state may allow transforming viruses to proliferate, potentially causing malignant transformation through integration of viral DNA into host genomes and/or triggering antigenic stimulation, thereby increasing the likelihood of genetic mutations in B cells (Fisher and Fisher 2004).

The mutations of SUZ12 often are found in some cancer, for example, SUZ12 mutations cause the malignant transformation of peripheral nerve sheath tumors (Zhang et al., 2014c).

For example, the activation of oncogenes or the inactivation of tumour suppressor genes, such as K-ras mutation and p53 mutation, could initially cause malignant progression (Huang et al, 1998).

DNA-repair mechanisms enable cells to maintain their genetic information by protecting it from mutations that may cause malignant growth.

Similarly, comparing exome sequences of matched lesional tissue and blood samples has yielded somatic disease mutations causing neoplastic conditions, both malignant and benign.

This point mutation not only causes malignant hyperthermia but also a health problem known as porcine stress syndrome (PSS) and the development of pale, soft, exudative (PSE) meat that leads to major economic losses in the pork industry.

The MBT repeat was originally identified in the Drosophila tumor-suppressor protein L 3 MBT and mutations of L 3 MBT gene cause malignant transformations of the optic neuroblasts [5].