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These results are generally consistent with our finding that purifying selection is removing mutations in essential genes or essential parts of genes and mutations causing extreme changes in protein length.
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We now report that many publicly available Drosophila stocks carry this mutation or a second, independent mutation in Cyp6d2 that also causes extreme sensitivity to camptothecin.
Unfortunately it's also hugely addictive - withdrawal means agonising death - and can cause extreme bodily mutations.
Richards, R.I. & Sutherland, G.R. Dynamic mutations: A new class of mutations causing human disease.
We reinforce the latter observation in Figure 1, which gives an example showing that extreme depth is necessary for accurate isoform abundance estimation for the dystrophin gene, a complex multi-isoform gene that can harbor mutations causing muscular dystrophy.
The para bss1 mutant is caused by a gain-of-function mutation in the voltage-gated Na+ channel gene that causes extreme seizure sensitivity.
We show that mutations in CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), a component of a ubiquitin ligase, cause extreme early flowering under SDs, and that this is largely dependent on CO activity.
From these results, an interesting observation can be made: The mutation causes more extreme base composition in the evolving genotypes, making the genotypes of different species distinct.
At its mildest, it causes extreme discomfort.
Ecstasy can also cause extreme thirst.
Williams' injury caused extreme fatigue.
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CEO of Professional Science Editing for Scientists @ prosciediting.com