Sentence examples for mutations causing constitutive from inspiring English sources

Indeed, more than eighty percent of human melanomas harbor somatic B-Raf or N-Ras mutations causing constitutive activation of MEK1 and 2 [2], [2].

We then altered our model to represent various cancerous situations such as Ras, B-Raf and EGFR mutations causing constitutive activation, as well as EGFR overexpression.

It is interesting to speculate that mutations causing constitutive CD117 phosphorylation may also collide with the intracellular traffic of CD117 and cause the molecule to accumulate in cellular organelles, such as the Golgi apparatus or the endoplasmic reticulum.

Analogous to JAK2,V617F these mutations cause constitutive JAK2 and signal transducer and activation of transcription (STAT) activation.

These mutations cause constitutive activation of Hh signaling that may result in uncontrolled proliferation of basal cells.

Both types of mutations cause constitutive activation of the FLT3 receptor resulting in constitutive downstream signaling via the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and the phosphatidylinositol-3 kinase/AKT (PI3K/AKT) pathways.

These two amino acids are catalytically important for GTPase activity; therefore, these mutations cause constitutive activation by disrupting the turn-off mechanism of Gs-alpha [Weinstein et al., 2004].

In this study, using A623V as a positive control, we utilized a combination of functional assays, site-directed mutagenesis and image techniques to demonstrate that this mutation causes constitutive activation of Gαs/cAMP and Gαq/11/IP cascade signaling, which suggests the key role of isoleucine at position 691 in maintaining the inactive state between TSHR and Gα protein.

In the latter strains the Q-L mutation causes constitutive activation of the respective G-alpha subunit.

The oncogenic BRAF V600E mutation causes constitutive activation of the Ras-Raf-MEK-ERK (RAS) signaling pathway, stimulating cellular growth, differentiation and survival.

The side chains of the ALK residues most frequently mutated in neuroblastoma [ 12] (Phe and Arg) make important contributions to these autoinhibitory interactions, and their mutation causes constitutive ALK activation.