Your English writing platform
Discover LudwigExact(4)
György and Corey said that although genetic mutations cause only a small percentage of hearing-loss cases, the viral delivery mechanism holds promise as a treatment for other types of hearing loss as well.
Current thinking is that major gene mutations cause only a small proportion of all cases and that in most cases, non-genetic factors play a part, probably in interaction with susceptibility genes.
In fact, most lethal mutations cause only very rare diseases.
If individual mutations cause only minor changes in phenotypes, gene flow and recombination might prevent adaptation to local environments [ 77].
Similar(56)
In our simulations, however, mutations affect phenotype in a cumulative way such that each mutation causes only a partial loss of protein function.
Unlike the NL3 R451C mutation, the R704C mutation caused only a roughly 35% reduction in NL3 expression [ 39].
Apparently, the rpl24b mutation caused only a minor deficiency in ribosome loading for the uORF-containing mRNAs.
Interestingly, the F180L mutation caused only about a two-fold decrease in the deacetylation activity of the enzyme.
Interestingly, the F180L mutation caused only around 2-fold decrease in the enzyme's deacetylation activity (see Figure 4 figure supplement 6).
The lack of PCD activation in the Sec24A mutant may be linked to the fact that the missense mutation caused only a partial loss of Sec24A function, affecting the anterograde trafficking of only a subset of cargos [ 39].
However, even if the mutation caused only partial ICR1 demethylation to take place in the female germline (grandmother and daughters), one would still expect less ICR1 methylation in third generation (the children with BWS), not more.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com