Mutations that cause mental retardation have not yet been found in the RSK4 and SREB3 genes, but RSK4 is strong candidate MRX gene because of its similarity to RSK2, a known MRX gene, and SREB3 because of its brain-specific expression pattern.
Most of these genes are human MRX genes, specific mutations in which cause mental retardation.
Furthermore, mutations in DYNC1H1 cause mental retardation with cortical neuronal migration defects (Vissers et al., 2010; Willemsen et al., 2012; Poirier et al., 2013).
Whole exome sequencing of the family revealed a novel mutation that causes mental retardation and severe developmental delays.
During a screen of the coding exons of 718 genes on chromosome X from 208 families for mutations causing X-linked mental retardation (XLMR), Tarpey et al. (2009) found mutations in three novel and several known disease genes, but could not, for most families, identify the genetic cause of XLMR, despite the identification of a large number of missense and even truncating mutations.
ZFHX1B (ZEB2/SIP1) mutations cause HSCR in the context of Mowat-Wilson syndrome, which also includes microcephaly, mental retardation, and dysmorphic facial features (31, 204).
Although MECP2 mutations cause RTT in females, milder mutations and duplications of MECP2 have been found in males with mental retardation (14, 15).
B) "That vaccines cause mental retardation".
At least 80 mutations cause transthyretin diseases, Dr. Kelly said.
Does city living cause mental illness?
