Sentence examples for mutations cause increased from inspiring English sources

The mutations cause increased aortic expression of components of the TGF-β signaling pathway.

Underlying fibrillin-1 gene mutations cause increased transforming growth factor-β (TGF-β) signaling.

Although several studies have noted that IDH mutations cause increased colony formation in soft agar and enhanced proliferation, two mouse models for leukemia found that IDH mutation primes cells by inducing an MDS- or MPN-like state.

These mutations cause increased ER stress, reduced calcium binding, interfere with calcium-dependant protein folding and hamper protein trafficking in vitro [13], [18], [24], [35], [36].

Further studies are needed to assess which mutations cause increased pathogenicity and to establish whether or not LCMV represents the only arenavirus present in European rodent populations.

Mutant clones of all three alleles were overrepresented in the adult eye when compared to clones of the parental FRT82B chromosome, suggesting that these Fbxl7 mutations cause increased tissue growth.

Other mechanisms have been identified in Streptococcus pneumoniae (including mutations in an RNA methyltransferase that methylates G2445 of the 23S rRNA and mutations causing increased expression of ABC transporter genes) and in Staphylococcus epidermidis.

To search for novel cytoprotective features of this pathway, we carried out a genetic mosaic screen for mutations causing increased lysosomal and/or autophagic activity in the Drosophila melanogaster larval fat body.

However, it remained possible that pif1Δ or exo1Δ mutations caused increased Stn1 or Ten1 levels.

SPG7 mutations caused increased mitochondrial biogenesis in patient muscle, and mitochondrial fusion in patient fibroblasts associated with the clonal expansion of mitochondrial DNA mutations.

Overall 3 of the 6 described hereditary TRPC6 mutations caused increased Ca2+ influx when transfected into HEK293 cells [20,21], but importantly pathological effects were only observed in the kidneys despite widespread expression throughout the body.