Sentence examples for mutations carry a from inspiring English sources

We therefore currently favour the alternative explanation that protective CTL responses tend to target regions of the viral genome where mutations carry a heavy fitness cost.

The vast majority of these mutations carry a typical ultraviolet light signature.

We find that on average chromosomal resistance mutations carry a larger cost than acquiring resistance via a plasmid.

Many of these mutations carry a fitness cost [ 45, 49] that appears to be negatively correlated with the activity of the mutant enzyme [ 55].

On average, most drug-resistance mutations carry a fitness cost (see Fig.  3) [ 44] whose magnitude positively correlates with the frequency of different resistance mutations in the clinic; resistant strains with the smallest fitness defect are most abundant [ 45, 46].

In vitro work has demonstrated that, although resistance mutations carry a fitness cost, counter-selection in the absence of an antibiotic can fail owing to compensatory adaptations that preclude a reversion to susceptibility (Andersson and Hughes 2010).

Patients with germline CDH1 mutations carry an increased risk of lobular breast cancer and colorectal cancer [ 64, 65].

DBA is characterized by broad phenotypic variability; moreover, some first-degree relatives of DBA-affected individuals with RPS19 mutations carry an identical mutation but display no observable phenotype (Willig et al., 1999).

Part of the answer, he found, was that some of those same mutations carried a highly positive trait as well: high creative ability.

Individuals heterozygous for the Factor VLeiden mutation carry a risk of venous thrombosis 5 7 times higher than in the general population.

Here we tested the hypothesis that women with an extremely high breast cancer risk (due to a BRCA1 mutation) carry a specific methylation signature in peripheral blood cells, which is also able to predict sporadic breast cancer incidence and death.