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LRR domains carrying the 3020insC did not induce similar perturbations to the cellular metabolite profile suggesting proteins with Crohn's-associated mutations cannot target bacterial metabolism due to their lack of direct binding to the bacteria (Figure 1).
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In addition, understanding the epigenetic mechanisms that underlie these alterations has also provided new therapeutic potential, even if the driver mutations cannot be targeted directly (e.g. HDACi, DNMT inhibitors) (Table 1) (Arrowsmith et al., 2012; Foulks et al., 2012; Helin and Dhanak, 2013; New et al., 2012; Plass et al., 2013).
The strategy of linking two cleavage domains, although successful in targeting mtDNA point mutations, cannot be used to target the break points of many mtDNA deletions (see Introduction).
Mutation hit-rate at a given locus needs to be evaluated because genome editing cannot target all loci with similar efficiencies.
"So we cannot target users under 13".
Central banks cannot target both their exchange rate and inflation.
The participant believes that mutations cannot be constructive (useful).
Currently you cannot target ads specifically to saved content.
This means that these two mutations cannot complement each other.
Those mutations cannot be detected with focus techniques.
Most anti-cancer agents cannot target cancer cells actively.
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