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The fact that both predicted human null mutations cannot rescue an xpd-null mutation in the fly system indicates that the system is capable of modeling the human XPD alleles.
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That the null mutation of dbl-1 cannot rescue mua-3 but RNAi knockdown of dbl-1 can suggest that complete knockout of dbl-1 does not help mua-3, but reduction of MUA-3 levels does.
Accordingly, a D. melanogaster HPat protein carrying mutations in the conserved Pat-C surface cannot rescue decapping in cells depleted of endogenous HPat.
This interpretation is confirmed since Rab5CA cannot rescue Notch signaling in awd mutant cells.
Y-BSC5 cannot rescue the lethality in G0361, however, suggesting that this line may contain other lethal mutations in addition to Smr.
To shed light into these principles, in this work we combined structural studies by X-ray crystallography with a rescue approach using a Syt1/7 chimera that cannot rescue neurotransmitter release in synaptotagmin-1 neurons, and attempted to endow the chimera with rescue activity with mutations that make the synaptotagmin-7 C2B domain more similar to the synaptotagmin-1 C2B domain.
Making divorce harder cannot rescue irretrievably broken marriages.
Even Connie Grappo's astute direction cannot rescue this ending.
We cannot rescue a whole continent and bring them here.
The bank cannot rescue banks that have too many bad loans and are insolvent.
Extra demand is welcome.China cannot rescue the world economy on its own.
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