Sentence examples for mutations cannot recapitulate from inspiring English sources
There are two possible reasons: either the activated AP2 mutations cannot recapitulate all of the normal functions of the AP2 complex, or there are other functions of FCHo beyond its actions on AP2.
It is likely that the activated AP2 mutations cannot recapitulate all of the normal functions of the AP2 complex, since it is known that FCHo has other functions beyond its actions on AP2, for example via interactions with Eps15 or Disabled-2 (Reider et al., 2009; Henne et al., 2010; Uezu et al., 2011; Mulkearns and Cooper, 2012; Umasankar et al., 2012; Mayers et al., 2013).
Genetically engineered mouse models can recapitulate rare variants, displaying some behavioral defects associated with schizophrenia; however, these mouse models cannot recapitulate the full genetic architecture underlying the disorder.
However, mice lacking ALS2 cannot recapitulate the complex disease phenotypes, despite the subclinical levels of motor dysfunction and axonal degeneration in aged animals [6], [20], [21].
In vitro models cannot recapitulate such complex end points.
In addition, in vitro experiments cannot recapitulate the dosing scheme that would be used in vivo.
The relative gradients of the VEGF isoforms are equal (8.4%/tip length) and thus cannot recapitulate isoform-dependent localization.
Of course, these fragment models show ligand-independent toxicity and therefore cannot recapitulate the specific features of SBMA.
But simple gain- or loss-of-function assays cannot recapitulate the complexity of the genetic landscape revealed by genome-wide association studies (GWAS) and deep sequencing.
Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies.
At the same time, noise trajectories predicted by assuming the incorrect, reverse topology (Hsp12 activates Msn2) cannot recapitulate the data (correlation of −0.15).
