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This is plausible as when robustness is very high, little variation becomes exposed to selection, and when robustness is very low, the conditionally adaptive mutations cannot accumulate because they are immediately exposed to selection.
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Similarly, accumulated mutations cannot explain why the cancer occurrences are not correlated with the lifespan among different biological species, e.g., thousands of year old trees without cancer versus a 12-day-old Drosophila with cancer, although they have the same DNA replication mechanisms [ 27, 28 ] and similar environmental risks that can cause mutations.
When chaperone becomes scarce, either because of increased need due to stress or due to a mutation in a chaperone, the accumulated destabilizing mutations cannot be buffered and the malfunctioning of proteins manifests in the mutant phenotype.
The theory underlying the mutation accumulation assay is that all mutations other than lethal mutations accumulate as if neutral.
Not having sex means this cannot happen, so mutations accumulate in each asexual line.
Microsatellite sites diverge rapidly due to their high mutation rate; however, point mutations accumulate more slowly.
In the mutational meltdown, deleterious mutations accumulate because the population size is low and thus subject to strong genetic drift (Lynch 2007).
In mtDNA mutator mice, mtDNA mutations accumulate leading to a rapidly aging phenotype.
Because selection eliminates mutations that disrupt P450 activity, mutations accumulate more slowly in the monomorphic and polymorphic populations.
Cancer cells divide a lot, so mutations can accumulate rapidly.
Mutations rapidly accumulate in the HIV-1 genome after infection.
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