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On the other hand, women harbouring homoplasmic mtDNA mutations can transmit mutated mtDNA to their children.
The cisconfiguration could determine the possibility that an individual carrying the two mutations can transmit the intact allele to offspring.
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Women harbouring heteroplasmic mtDNA mutation can transmit a wide range of heteroplasmy levels to different offspring within the same sibship.
We next focused on germ cells that become gametes, because only they can transmit mutations to future generations.
If mutant ES cells partially differentiate into germ cells, the founder mice can transmit the mutation to the next generation of mice.
Evidence provided in this work indicates that pollen from mutants homozygous for p5cs1 and heterozygous for p5cs2 can transmit the p5cs2 mutation with an overall frequency of about 0.8%, and that mutants with decreasing levels in proline content [ 2, 3, 24] have increasing problems in pollen viability indicating that proline is required for male fertility.
Various studies have reported mutations associated with sulfa resistance in P. jirovecii strains isolated from colonized patients, who can transmit the mutant genotype to PCP-susceptible individuals.
The problem is addressed by inducing the transposition during anther culture so that selected mutations can be transmitted and then regenerated to a homozygous state.
These mutations can be transmitted through the germline to make stable lines.
These mutations can be transmitted through the germline, and this method offers the opportunity to generate a desired mutant fly line within one month.
To determine whether TALEN-induced mutations can be transmitted germinally, we first identified parental transgenic lines with high frequencies of somatic mutagenesis.
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