Sentence examples for mutations can suppress from inspiring English sources
nhaA1 creates a frameshift in codon 17, showing that null nhaA mutations can suppress the calcium auxotrophy.
KRAS as a secondary oncogene was selected as KRAS mutations can suppress cMYC-induced apoptosis in rat fibroblasts via PI3K/AKT signaling, and KRAS mutations are frequently detected in MM.
We have now revealed that both Rab3GAP1/ rbg-1 and Rab3GAP1/ rbg-2 mutations can suppress the RAB-3 mis-localization phenotype in snt-1 mutants, implying that Rab3GAP does indeed function as a complex to participate in the SNT-1-mediated regulation of the RAB-3 cycle.
Because the four suaA mutations have sequence changes in eRF1, all these mutations are in eRF1 like supE7 (it seems likely that the cross data were incorrect but it has not been possible to repeat this cross because the supE7 strain is no longer viable) and the suaA mutations can suppress all three classes of chain termination codon.
The A89V mutation can suppress the melanosome transport defects, but not the vision impairment observed with the loss of bbs3.
These results suggest that the Δ pkaA mutation can suppress the ΔsnfA mutation and that both genes are somehow genetically interacting.
VPS52 is a regulator of actin with known genetic interactions with ACT1; mutations in VPS52 can suppress temperature sensitive alleles of ACT1 [29].
Both suaA and suaC mutations result in a number of pleiotropic changes, which could result from read-through of proteins; in addition, it has been suggested for both eRF1 and eRF3 that they might have a translation-independent role, because eRF1 and the myosin-light chain have been shown to interact in S. cerevisiae and mutations in eRF1 can suppress defects in cytokinesis (Valouev et al. 2004).
We found that sticky mutations can dominantly suppress a dFmr1 gain-of-function phenotype in the developing eye, while phenotypes produced by RNAi knock-down of sticky were enhanced by dFmr1 RNAi and a dFmr1 loss-of-function mutation.
Thus, "chemical suppression" screens will help us devise cautionary measures in chemotherapy to avoid administering drugs that can suppress mutations in the cancer genome.
Several oncogenic mutations and signalling pathways can suppress AMPK signalling, which uncouples the fuel signals from the growth signals and allow tumour cells to divide under abnormal nutrient conditions.
