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Most of the spontaneous mutations are neutral or deleterious, while disadvantage mutations will be discarded, and neutral mutations can still retain.
However, these mutations can still be detected as long as we sequence the genomic DNA with a high enough coverage.
As a result, the NFS mutations can still be sustained without major effects on protein function if the affected amino acid is non-essential for biological activity.
Other mutations can still be implicated in resistance however, as described in LNZ-resistant Enterococci, Staphylococci and S. pneumoniae [ 21, 22, 26, 29, 36].
Even some genes with gross mutations can still be transcribed, leading to a broader definition of pseudogenes that may include many unrecognized elements [ 16].
doi: 10.7554/eLife.07918 Image Stem cells with TERT promoter mutations can still differentiate into more specialized cells such as nerve cells Most cells in the human body have a limited lifespan.
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Strains with either the eso1-G799D eso1-W804G04G mutation can still grow on the plates containing FOA, indicating that eso1 mutations do not have significant effects on the silencing of the ura4+ reporter gene at the outermost centromeric repeats, innermost centromeric repeats or mating type region.
β-catenin induced a ∼30%% increase in colony formation in HCT116 and HepG2 cells, in consistency with data on cyclin D1 promoter activity, thus supporting the hypothesis that despite activating β-catenin mutations, cells can still respond to stimuli inducing further increases in β-catenin levels.
One, test data that kills all mutants generated by current mutation tools can still miss detection of some common logic faults because such tools lack appropriate logic mutation operators.
Likewise, males homozygous for mutations disrupting serotonin synthesis can still sometimes perform wild-type turns implying that neurotransmitters other than serotonin also act in tail curling.
We know that the KE family's problems are caused by a very rare mutation, yet their difficulties can still be quantified in terms of low language test scores.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com