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These data establish that TERT promoter mutations can promote immortalization and tumorigenesis of incipient cancer cells.
Studies of mutated loxP sites have revealed that two classes of mutations can promote Cre-mediated insertion or replacement.
They reported ~140 driver genes whose intragenic mutations can promote or drive tumorigenesis.
These data indicate that the NKD1 mutations can promote β-catenin stabilization and colonic cell proliferation.
3) ALS mutations can promote the assembly of SOD1 into amyloid by mechanisms which include facilitating the loss of metals and reduction of the intramolecular disulfide bond.
PSEN2 mutations can promote apoptosis.
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The sole action of drift and mutation can promote phenotypic differentiation or reproductive isolation [ 24].
These data indicated that DDR2 S131C mutation can promote the migratory and invasive phenotype of lung SCC cells.
Recently, we have found that environmentally induced epigenetic transgenerational inheritance of disease and phenotypic variation can promote genetic mutations (i.e., CNV) in later generations (Skinner MK, Guerrero-Bosagna C, Haque MM, unpublished data).
In each cell cycle, the replicating genome is at risk of de novo mutations, which can promote the development of cancer.
Although such analyses have provided statistical criteria by which to define driver mutations that can promote tumor progression, they limit the perspective to single points in time.
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