Sentence examples for mutations can play from inspiring English sources

In RNA fitness landscapes with interconnected networks of neutral mutations, neutral precursor mutations can play an important role in facilitating the accessibility of epistatic adaptive mutant combinations.

Although there were reports of somatic mutations specifically at sites of known mtDNA regulatory elements, the available data from hybrid studies and post-mortem brain examinations did not provide conclusive proof that somatic mtDNA mutations can play a major or dominant role in AD aetiology [10], [11].

These examples demonstrate that unstable/recurrent mutations can play a critical role in the assignment of haplogroups and therefore must be properly handled in automated software solutions.

A similar phenomenon seems to occur in natural evolution, where functionally neutral but stabilizing mutations can play a key role in adaptive evolution by counterbalancing the destabilizing effects of other functionally beneficial mutations [ 37].

However, our findings do indicate that compensatory mutations can play a major role in producing antagonistic epistasis and thus slowing the decay in mean fitness under random mutation accumulation.

However, when selection is weak (long pathways, Gaussian fitness), the probability of fixation can be substantially greater than zero, even in large populations and, in this case, segregating hypomoprhic mutations can play a large role in substantially reducing the probability of fixation of loss-of-function alleles on the Y (supplementary fig. S10, Supplementary Material online).

To determine whether mutation can play a role in microcolony initiation, biofilm growth of P. aeruginosa PAO1 WT, ΔmutS, ΔmutL and complemented mutant strains were compared using confocal scanning laser microscopy (Figures 2 and 3).

While these two cases can be qualitatively similar in very small populations, they lead to very different dynamics in larger populations where the sign of the effect of the intermediate mutation can play a crucial role.

Technical advances developed to improve clinic-based mutation screening can play a role in the targeted mutation breeding of crops.

Thus, mutation analysis can play an important role in drug discovery and personalized healthcare.

Thus, mutation analysis can play an important role in drug discovery and drug development.