If this mutation can mimic the phosphorylated form of DegS in vivo, it would indicate that the serine phosphorylation event could have the potential to regulate social behaviours regulated at low DegU∼P levels in B. subtilis.
Missense mutations in the ectodomain can mimic ligand-binding, leading to ligand-independent cleavage and release of the intracellular domain and, therefore, to constitutive activity.
In addition, the pseudogene sequence can mimic disease-causing mutations in the true gene.
These findings were later put into question by Meierhofer et al. [11], who showed that platelet transfusion can mimic somatic mtDNA mutations.
GEMMs are a useful tool to investigate gene function, as they can mimic cancer-related mutations and provide a model system in which to study tumorigenesis in the setting of a functioning tissue microenvironment.
"GEMMs are a useful tool to investigate gene function, as they can mimic cancer-related mutations and provide a model system in which to study tumorigenesis in the setting of a functioning tissue microenvironment" One of the things that we have incorporated into these models is the ability to introduce a conditional short-hairpin RNA that targets a gene of interest.
To test if any aspartate mutation in the BubR1 KARD domain can mimic phosphor-serine/threonine with respect to direct B56 binding, we generated all 8 mutant combinations at these three sites and measured that binding affinities with B56γ1 using ITC.
Furthermore, a mutation in another cellulose synthase gene, rsw1, also results in activation of jasmonic acid signaling, and cellulose biosynthesis inhibitors can mimic the cev1 mutant phenotype in wild-type plants, including the activation of pathogen response genes [ 18].
In the future, it might be possible to develop drugs that can mimic the effects of these gene mutations to treat cancers.
Recombination should not produce misleading interpretations of populations with limited or nonexistent gene flow; however, it can mimic the traces of population size expansion, underestimate divergence times, and mask ancient polymorphisms as recurring mutations [ 27, 29].
