Sentence examples for mutations can generate from inspiring English sources

But the mutations can generate an incredible number of effects on the phenotype, and most of them will be deleterious under any circumstances, if not lethal.

These compensatory mutations can generate variants with high transmission fitness (δrH), comparable to that of the wild-type strain.

Genetic diseases caused by nonsense or frameshift mutations can generate premature termination codons, which usually trigger nonsense-mediated mRNA decay (NMD).

Uniquely, ENU-induced mutations can generate not only null alleles but also partial loss-of-function (hypomorphic) and dominant-negative alleles (Acevedo-Arozena et al., 2008).

Note that some nonsense and frameshifting mutations may not generate null alleles if they only disrupt a short C-terminal region of the encoded protein, whereas some missense mutations can generate null alleles.

Although adaptation by new mutations vs. adaptation from standing genetic variation are sometimes thought of as distinct mechanisms (B arrett and S chluter 2008), we have found that even in initially clonal populations, new mutations can generate variation rapidly enough (even while selection acts) to strongly influence the dynamics of adaptation.

Using this method, we show here that MCU does recapitulate key features of I MiCa, and show that a single point-mutation can generate resistance to pharmacologic inhibition.

However, the fact that the JAK2+ syndromes exhibit various clinical features raises the question of how a single mutation can generate different MPNs and strongly suggests that other acquired events have to occur, at least in ET and PMF.

With the efficiency up to 88% of injected embryos having mutations, Cas9 can generate mutations rapidly [ 16].

Microbial genomes commonly incur variations from insertions, deletions, or mutations that can generate false-negative results if the variation resides within a probes' targeted region.

Those experiments reveal that mutations alone can generate a considerable amount of phenotypic variability, and drive the derived lines several units of residual standard deviation away from the phenotypic value of the initial homozygous individual.