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mtDNA mutations can exist as point mutations, nucleotide insertions or deletions, and large deletions.
Even though mutations can exist in satellite sequences, long stretches of satellite type DNA conserve the established 100% identity and 300 bp thresholds.
Mutation rates are thought to be elevated on smaller time scales (i.e. within species) when compared to greater evolutionary distances between species as deleterious mutations can exist at moderate frequencies within species.
Severe mutations can exist and even be passed between generations if they exist in a state of heteroplasmy where some copies of the genome contain the mutation and some are wild type.
38, 39 That we find EFHC1 P77T-R221haplotypepe to be as high as 8% in populations of West African ancestry is evidence that some EFHC1 coding mutations can exist in relatively benign states in some backgrounds (e.g., West Africans) but perhaps not in others (e.g., Hispanics in Los Angeles).
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In the context of genetic disorders, even though the underlying harmful mutation can exist in all the cells in the human body, it most often wreaks havoc only in a few tissues.
Gene mutations can be induced by radiation as a result of chromosomal translocations.
Mutations can be detected in 90%.
A mutation in BRAF was found in two aCP cases, both of which had a coexisting CTNNB1 mutation, demonstrating that although the majority of aCPs do not contain BRAF mutations, they are not exclusive to pCPs and can exist with mutations in CTNNB1.
Our findings also emphasize mechanisms of both primary and acquired resistance; specifically, mutations or aberrations in other RTKs can exist concurrently with EGFR mutations and can even be present prior to EGFR-targeted therapy.
Different mutations with different therapeutic impact can exist synchronously in a patient[ 81]].
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