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Hence, it seems unlikely that the mutated CLL cases had acquired VH gene mutations by the alternative CD40-independent pathway.
Charles Darwin, in his theory of the selection of mutations by the environment, sought to vindicate apparent progress in the organic realm without recourse to an extraneous god.
These data elucidate the biophysical basis for the selection of hinge region insertion mutations by the HI virus.
Furthermore, short sequences allow the accurate massive inter- and intra-species identification of point mutations by the SSCP technique.
First, transmission could decrease the accumulation of mutations by the loss of low-proportion mutants because only a limited portion of the virus population will be transmitted.
This technology efficiently induces DNA double strand breaks at the targeted genomic sequence and results in indel mutations by the error-prone process of nonhomologous end joining DNA repair or homologous recombination with a DNA repair template.
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Study design: Of a total of 86 individuals analyzed for Δ32 mutation by the PCR technique, 36 scored HIV seropositive (SP) and 50 were ESN.
The supression of the fadD2 mutation by the fadD1 mutation, in the ΔfadD2D1 mutant, reversed the reduction in virulence factor expression seen in the single fadD1 mutation alone (Fig. 7).
The amount of patients with different mutation by the three assays was in Table 1.
Finally, sample ID 96 was positive for the c.34 G > T mutation by the TheraScreen kit and the c.34 G > T and c.35 G > A mutations by CADMA.
To get the rigor-KCBP construct, we introduced threonine (ACT) 982-to-asparagine (AAC) mutation by the PCR-based mutagenesis.
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