Sentence examples for mutations by decreasing from inspiring English sources

Thus, NEP transcription initiation may avert detrimental effects of point mutations by decreasing specificity.

We attempt to simulate this mutation by decreasing the X50 values for the Akt OR function by 100%, which predicts a 1.6-fold increase in Akt* and no change in ERK*.

Activating kinase mutations can be captured by decreasing the EC50 value in upstream activating connections and thus simulating hyper-activity, conversely for deactivating mutations.

This rescue effect by the dpp heterozygous mutations is unlikely caused by decreasing GSCs.

These researchers report that a reduction in the PMF, as a consequence of these mutations, increases aminoglycoside resistance by decreasing the uptake of these antibiotics.

Although these findings were consistent with the point mutation rendering the latent myostatin complex resistant to activation by BMP-1/TLD proteases, it was important to rule out the possibility that the point mutation caused increased muscling by decreasing myostatin expression levels.

We approximate the Muller's ratchet by decreasing the mutation rate so that a mutation in the model corresponds to many mutations in real genomes.

Thus, in our approach to tumour growth, mutations can lead to hyperplasia by decreasing the costs of somatic processes (maintenance or growth) or by increasing the energy supply per cell.

DNA mismatch repair is a highly conserved process that maintains the fidelity of genomes by decreasing the mutation rate 100- to 1000-fold (Kunkel and Erie 2005).

We did not expect TRIM5αhu7KR to restrict infection when expressed in cells because TRIM5αhu residues Lys367 and Lys368 are located in the surface-exposed PRYSPRY loop 5 (Supplementary Fig S8E) (Biris et al, 2012), and their simultaneous mutation can impair restriction activity by decreasing binding to N-MLV capsid protein (Sebastian et al, 2009).

The use of NCCLS susceptibility breakpoints for newer fluoroquinolones underestimates a high proportion of low-level ciprofloxacin-resistant strains with first-step mutations whose detection should be improved by decreasing those breakpoints as previously suggested (11, 39 ).